Hi Dr. Steve, thank you for your help here. I’ve taken the time to go through related posts and, currently, I’m eagerly awaiting the shipment of bupleurum and kudzu.
Rhodes, my 1-year-old toy Aussie, was diagnosed with SRMA in March (at ~5 months of age) due to noticing her constantly being hunched and walking a bit stiff. The MRI indicated slightly indistinct SAS/CSF on T2myelo, suggestive of inflammatory meningitis. Despite a CSF sample with a slight neutrophil elevation and contamination, we proceeded with prednisone treatment. She also deals with low-grade luxating patellas, contributing to persistent back pain according to her vets. This sensitivity bever goes away and she gets slightly hunched after a few steps most of the time despite medication, chiropractic care, acupuncture, and laser therapy. Anyway, She was taking only prednisone but I felt I noticed a relapse (probably immature) so now she has been on prednisone (1.25mg every second day) and cyclosporine twice daily for about 6 weeks so far and due to taper again.
My questions:
Post-cyclosporine initiation, she encountered chronic UTIs, recurring about 3 times now despite a 3-week course of clavamox and the use of bladder treats each time. Any advice on managing this issue would be greatly appreciated.
The primary concern revolves around her sensitive stomach. Despite administering cyclosporine 1.5-2 hours post-meals (she’s on just food for dogs -joint and skin formula with slippery elm), her tummy gurgles, tear ducts overflow, and she experiences nausea/vomiting. She also is always itching like crazy but does so less with the fish formula and this skin one from JFFD. Our routine involves meals at 7:30-8 am with her prednisone every second day, and cyclosporine at 9:30 am and pm every day.
I’m also attaching her initial findings here for your reference. Any additional thoughts you might have would be invaluable, especially considering her fluctuating symptoms of more unexplainable back sensitivity some days than others and this stomach difficulty. Thank you sincerely for your time and expertise.
Dr. Steve's Advice - it's alarming to have a diagnosis of meningitis in a dog of such young years (or rather, months!). I understand the basis for the diagnosis, but at least half of me is questioning it, since both findings supporting it (i.e., the MRI and the CSF analysis) are pretty subtle. It's probably wise to seek out local holistic help to see what might really be going on.
Meanwhile, I'd start with the skin symptoms. If we can get them to improve, then we know we are regulating your dog's immune system sufficiently that you will have probably undermined the tendency to SRMA. For that, I'd recommend adding:
- Cessorex (https://goldstandardherbs.com/products/Original-Cessorex-85g-p647327434) from Gold Standard Herbs
- a Lactobacillus or Bacteroides probiotic, such as Gussys Gut (https://gussysgut.pxf.io/c/4643206/1738316/19832)
Meanwhile, continue whatever fresh food diet seems best tolerated.
These two items will start to remove the tendency toward immune mediated disease of any cause in your dog's body, in part by sealing the leaky gut.
It's fine to use this with the Bupleurum and Kudzu, if it has arrived and you've already started it. If all signs of SRMA had been wiped out by the drugs, back off on the cyclosporine to allow some minor recurrence. Then wait until the herbal formulas 'catches up', causing that uptick in symptoms to disappear. You're then ready to lower the dose of cyclosporine (and/or prednisone) again. Once your dog is symptom-free and off drugs, you're clear to start reducing the B&K
If the B&K has arrived, but you haven't started it, and the drugs are resolving all evidence of the SRMA, then proceed with just the Cessorex for now, but add Lift the Qi by Kan Essentials (available through the same place as the Bupleurum and Kudzu) can help the GI symptoms and tendency to recurrent UTIs, by rescuing local immunity in the gut and bladder. As skin/bladder/GI symptoms improve, start reducing the cyclosporine in the step-wise fashion mentioned above, waiting with each reduction until the herbs have caught up.
I can think of a couple of differentials for the hunching, if the immune suppressants aren't doing that good a job of getting rid of SRMA symptoms. One is a 'Wind invasion' where the real problem is poor circulation to your pup's back, causing back spasm and hunching. Candidate treatments include Lumbrex (https://goldstandardherbs.com/products/Original-Lumbrex-85g-647327437) Another, given the GI weakness being revealed, is Free the Sinews by Kan Essentials.
The second possibility, though, is a tendency to gastric ulcer which might not show on any test and would be perhaps the most conceivable of all the diagnoses to exist in a young dog. For that, I would use Glehnia and Rehmannia Combination from Kan Essentials. It is safe to use with Cessorex and Lift the Qi (and B&K, if it's already in use).
Given the complexity of the answer, you can see why it's almost wiser to have a skilled local practitioner guide you through this, but maybe there is enough help here to get you through it, so your dog isn't chained to such hard-hitting drugs at such a delicate age
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